Orillia Fire Chief Chris Ferry says two occupants of a George Street home were alerted about a fire in the residence by working smoke alarms.
Crews responded to the home around 3 a.m. Wednesday.
Ferry says when firefighters got there, the house was fully engulfed and flames had already extended into the roof.
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The occupants got out safely, but two pets are unaccounted for.
One vehicle in the driveway was burned, and a second vehicle had painted burned off it, according to Ferry.
A neighbouring home suffered heat damage.
The fire is not considered suspicious.
The cause has not been determined.
