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Two inmates that Ontario Provincial Police says have a "violent criminal history" have escaped from the Beaver Creek Institution in Gravenhurst.
Police say the men, ages 68 and 70, fled from custody Wednesday in a grey or silver sedan.
One of the inmates has ties to Toronto and British Columbia, the other has ties to Gravenhurst.
If seen, do not approach, police said in a post to Facebook.
The force is warning the public not to approach the inmates if they spot them.
Correctional Service of Canada spokesperson Mike Shrider said the agency "will investigate the circumstances of this incident."
"We work closely with law enforcement to ensure they have the information to execute the warrant and return the offender to our custody as quickly as possible," Shrider said in an emailed statement, adding that escapes from federal institutions are "rare."
Shrider also said inmates who escape can be subject to a review of their security classification or additional charges.
Wednesday's escape marks the second at the prison since January, when a 41-year-old man fled from the grounds before he was found by police two hours later.
with files from The Canadian Press