Southern Georgian Bay OPP was contacted by a member of the public on Sunday evening for a wellness check of a family member.
Police went to a Hugel Avenue hotel in Midland where they located two individuals. Also in the room, police say they found a number of prescription pills and a handgun.
A 21-year-old Springwater Township woman and a 20-year-old Tiny Township man were charged with firearm and drug-related offences.
They were released and ordered to appear in a court at a future date.